P4480High mobility group box-1 (HMGB1) protein-induced cardioprotection in sheep with acute myocardial infarction
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چکیده
منابع مشابه
High-Mobility Group Box 1 Protein in Myocardial Infarction: Should it be Stimulated or Inhibited?
High-mobility group box 1 (HMGB1) protein was originally identified as a non-histone nuclear protein that stabilizes the nucleosome structure and regulates gene transcription 1). HMGB1 is highly conserved and ubiquitously expressed in the nucleus of almost all mammalian cells. In 1999, Wang et al. 2) reported that HMGB1 is released from activated macrophages, and extracellular HMGB1 acts as a l...
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High mobility group box 1(HMGB1), originally described as a DNA-binding protein, can also be released extracellularly and functions as a late mediator of inflammatory responses. Although recent reports indicated that the receptor for advanced glycation endproducts (RAGE), as well as Toll-like receptors (TLR2 and TLR4), were involved in cellular activation by HMGB1, there has been little evidenc...
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ژورنال
عنوان ژورنال: European Heart Journal
سال: 2017
ISSN: 0195-668X,1522-9645
DOI: 10.1093/eurheartj/ehx504.p4480